Emotional volatility and mood fluctuations (including anxiety, depression and hypomania) have been reported in the days and weeks following a psychedelic experience.
Clinical trials with psychedelics have excluded individuals with bipolar disorder, and most have excluded individuals with a family history of bipolar disorder, due to the perceived risk of occasioning a manic episode or inducing a rapid mood shift.
Psychedelic therapists, clinics and retreat centres should prepare participants for the potentiality of adverse effects; specifically, they should advise individuals that they could be in a mild altered state of consciousness for a period of time after their psychedelic experience.
There is at present very little research on the integration challenges that individuals could potentially face following a psychedelic experience.
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